Endocrine Abstracts

Recent data have shown that, in parallel to its transcriptional action down-regulating TSH synthesis, triiodothyronine (T3) also acts on posttranscriptional steps of beta TSH synthesis, reducing the polyadenylation and translational rate of the beta TSH mRNA, when acutely administered to thyroidectomized rats. This study aimed to investigate whether these effects also occur in TalphaT1 cells, and if they are dependent on gene transcription, which would characterize ...

Glyphosate is a broad spectrum herbicide that is effective against weeds, especially in association with transgenic glyphosate resistant crop systems, and represents approximately 30% of all herbicides used in agriculture. It was demonstrated that glyphosate has an activity of endocrine-chemical disruptor (ECD) in the reproductive axis, altering the production of testosterone and causing disturbances on the reproductive development of male offspring from dams treated during th...

Several studies demonstrated that the thyroid hormones (TH) downregulate the transcriptional rate of beta and alpha TSH subunits. Recent data showed that T3 also acts posttranscriptionally reducing the polyadenylation and translational rate of the beta TSH mRNA, when acutely administered to thyroidectomized (Tx) rats. This study aimed to investigate whether similar effects occur for the alpha subunit synthesis after acute administration of T3 or T4</...